Sex Differencesin Immune Responses in Guinea Pigs to Cephalothin
نویسنده
چکیده
Guinea pigs of two strains, outbTed Hartley and inbred Strain 2, were immunized subcutaneously with cephalothin (CET, 20 mglbody) alone, without adjuvant. Immune responses to the antibiotic were assessed by guinea-pig passive cutaneous anaphylaxis (GP-PCA) and active systemic anaphylaxis (GP-ASA) reactions. The immune response to CET in the female Hartley guinea pigs was higher than that in the males. In contrast, no ditrerence in response to CET in Strain 2 guinea pigs was observed between males and females. These results suggested that female Hartley guinea pigs possessing a higher response should be employed in antigenicity studies involving the i9 -lactam antibiotics.
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